Melanosomal formation of PMEL core amyloid is driven by aromatic residues
Abstract
PMEL is a pigment cell protein that forms physiological amyloid in melanosomes. Many amyloids and/or their oligomeric precursors are toxic, causing or contributing to severe, incurable diseases including Alzheimer’s and prion diseases. Striking similarities in intracellular formation pathways between PMEL and various pathological amyloids including Aβ and PrP Sc suggest PMEL is an excellent model system to study endocytic amyloid. Learning how...
Paper Details
Title
Melanosomal formation of PMEL core amyloid is driven by aromatic residues
Published Date
Mar 8, 2017
Journal
Volume
7
Issue
1
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