Sonic Hedgehog Signaling in Limb Development
Abstract
The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the posterior margin of the vertebrate limb bud. Detailed analyses have revealed that Shh has the properties of the long sought after polarizing region morphogen that specifies positional values across the antero-posterior axis (e.g., thumb to little finger axis) of the limb. Shh...
Paper Details
Title
Sonic Hedgehog Signaling in Limb Development
Published Date
Feb 28, 2017
Volume
5
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