Structural and functional insight into pan-endopeptidase inhibition by α2-macroglobulins
Abstract
Peptidases must be exquisitely regulated to prevent erroneous cleavage and one control is provided by protein inhibitors. These are usually specific for particular peptidases or families and sterically block the active-site cleft of target enzymes using lock-and-key mechanisms. In contrast, members of the +1400-residue multi-domain α2-macroglobulin inhibitor family (α2Ms) are directed against a broad spectrum of endopeptidases of disparate...
Paper Details
Title
Structural and functional insight into pan-endopeptidase inhibition by α2-macroglobulins
Published Date
Aug 28, 2017
Journal
Volume
398
Issue
9
Pages
975 - 994
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