Transcription control by the ENL YEATS domain in acute leukaemia
Abstract
Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion partners belies a dependency on transcription control. Despite recent progress made in targeting chromatin regulators in cancer, available therapies for this well-characterized disease remain inadequate, prompting...
Paper Details
Title
Transcription control by the ENL YEATS domain in acute leukaemia
Published Date
Mar 1, 2017
Journal
Volume
543
Issue
7644
Pages
270 - 274
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Notes
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