Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding

Volume: 7, Issue: 1
Published: Mar 3, 2017
Abstract
WaterLOGSY is a popular ligand-observed NMR technique to screen for protein-ligand interactions, yet when applied to measure dissociation constants (KD) through ligand titration, the results were found to be strongly dependent on sample conditions. Herein, we show that accurate KDs can be obtained by waterLOGSY with optimised experimental...
Paper Details
Title
Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding
Published Date
Mar 3, 2017
Volume
7
Issue
1
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.