Detecting DNA cytosine methylation using nanopore sequencing
Abstract
A hidden Markov model (HMM)-based tool enables detection of 5-methylcytosine (5-mC) from single-molecule nanopore-sequencing data generated directly from human genomic DNA without chemical treatment. In nanopore sequencing devices, electrolytic current signals are sensitive to base modifications, such as 5-methylcytosine (5-mC). Here we quantified the strength of this effect for the Oxford Nanopore Technologies MinION sequencer. By using...
Paper Details
Title
Detecting DNA cytosine methylation using nanopore sequencing
Published Date
Feb 20, 2017
Journal
Volume
14
Issue
4
Pages
407 - 410
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