Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis
Abstract
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Dietary fibers capable of modifying gut barrier and microbiota homeostasis affect the progression of type 1 diabetes (T1D). Here, we aim to compare modulatory effects of inulin-type fructans (ITFs), natural soluble dietary fibers with different degrees of fermentability from chicory root, on T1D development in nonobese diabetic mice.
Methods and results
Female nonobese diabetic mice were weaned to long- and short-chain ITFs [ITF(l) and...
Paper Details
Title
Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis
Published Date
Mar 24, 2017
Volume
61
Issue
8
Pages
1 - 11
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Notes
History