Synthetic Biomarker Design by Using Analyte‐Responsive Acetaminophen

The use of synthetic biomarkers is an emerging technique to improve disease diagnosis. Here, we report a novel design strategy that uses analyte‐responsive acetaminophen (APAP) to expand the catalogue of analytes available for synthetic biomarker development. As proof‐of‐concept, we designed hydrogen peroxide (H 2 O 2 )‐responsive APAP (HR‐APAP) and succeeded in H 2 O 2 detection with cellular and animal experiments. In fact, for blood samples...