Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Abstract
Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or if subtypes of CAFs with distinct phenotypes in PDA exist. We identified a CAF subpopulation with elevated expression of α-smooth muscle actin...
Paper Details
Title
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Published Date
Feb 23, 2017
Volume
214
Issue
3
Pages
579 - 596
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