Extracellular renalase protects cells and organs by outside-in signalling

Volume: 21, Issue: 7, Pages: 1260 - 1265
Published: Feb 26, 2017
Abstract
Renalase was discovered as a protein synthesized by the kidney and secreted in blood where it circulates at a concentration of approximately 3-5 μg/ml. Initial reports suggested that it functioned as an NAD(P)H oxidase and could oxidize catecholamines. Administration of renalase lowers blood pressure and heart rate and also protects cells and organs against ischaemic and toxic injury. Although renalase's protective effect was initially ascribed...
Paper Details
Title
Extracellular renalase protects cells and organs by outside-in signalling
Published Date
Feb 26, 2017
Volume
21
Issue
7
Pages
1260 - 1265
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