Thiolated chitosan as mucoadhesive polymers for buccal drug delivery

Buccal mucosa has been interested for local and systemic drug delivery due to the avoidance of gastrointestinal enzyme degradation and hepatic first pass metabolism. However, buccal drug delivery needs to be designed as mucoadhesive dosage forms by mucoadhesive polymers. Chitosan is a natural mucoadhesive polymer. The positive amino groups of chitosan interact with anionic substructures in mucus layer to form electrostatic mucoadhesive...