Homologous recombination deficiency (HRD) testing in ovarian cancer clinical practice: a review of the literature

Volume: 4, Issue: 1, Pages: 4 - 4
Published: Feb 22, 2017
Abstract
Until recently our knowledge of a genetic contribution to ovarian cancer focused almost exclusively on mutations in the BRCA1/2 genes. However, through germline and tumor sequencing an understanding of the larger phenomenon of homologous recombination deficiency (HRD) has emerged. HRD impairs normal DNA damage repair which results in loss or duplication of chromosomal regions, termed genomic loss of heterozygosity (LOH). The list of inherited...
Paper Details
Title
Homologous recombination deficiency (HRD) testing in ovarian cancer clinical practice: a review of the literature
Published Date
Feb 22, 2017
Volume
4
Issue
1
Pages
4 - 4
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