Insoluble Off-Pathway Aggregates as Crowding Agents during Amyloid Fibril Formation
Abstract
The study of drug candidates for the treatment of amyloidosis and neurodegenerative diseases frequently involves in vitro measurements of amyloid fibril formation. Macromolecular crowding and off-pathway aggregation (OPA) are, by different reasons, two important phenomena affecting the scalability of amyloid inhibitors and their successful application in vivo. On the one hand, the cellular milieu is crowded with macromolecules that drastically...
Paper Details
Title
Insoluble Off-Pathway Aggregates as Crowding Agents during Amyloid Fibril Formation
Published Date
Mar 8, 2017
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