Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis in cell‐autonomous fashion

Ca 2+ is a universal signal transducer which fulfills essential functions in cell development and differentiation. CACNA1C , the gene encoding the alpha‐1C subunit (i.e., Ca v 1.2) of the voltage‐dependent l ‐type calcium channel (LTCC), has been implicated as a risk gene in a variety of neuropsychiatric disorders. To parse the role of Ca v 1.2 channels located on astrocyte‐like stem cells and their descendants in the development of new granule...