Cdc20: At the Crossroads between Chromosome Segregation and Mitotic Exit

Volume: 42, Issue: 3, Pages: 193 - 205
Published: Mar 1, 2017
Abstract
Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) and a key cofactor of the anaphase-promoting complex or cyclosome (APC/C) E3 ubiquitin ligase, thus regulating APC/C ubiquitin activity on specific substrates for their subsequent degradation by the proteasome. Here we discuss the roles of Cdc20 in SAC signalling and...
Paper Details
Title
Cdc20: At the Crossroads between Chromosome Segregation and Mitotic Exit
Published Date
Mar 1, 2017
Volume
42
Issue
3
Pages
193 - 205
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