Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes

Published on Jan 1, 2017in Oxidative Medicine and Cellular Longevity4.87
· DOI :10.1155/2017/6437467
Dajun Zhao2
Estimated H-index: 2
Jian Yang14
Estimated H-index: 14
Lifang Yang4
Estimated H-index: 4
Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways, endoplasmic reticulum (ER) stress, increased basal oxidative state, and decreased antioxidant defense and autophagy may render diabetic hearts more vulnerable to MI/R injury. Oxidative stress and mTOR signaling crucially regulate cardiometabolism, affecting MI/R injury under diabetes. Producing reactive oxygen species (ROS) and reactive nitrogen species (RNS), uncoupling nitric oxide synthase (NOS), and disturbing the mitochondrial quality control may be three major mechanisms of oxidative stress. mTOR signaling presents both cardioprotective and cardiotoxic effects on the diabetic heart, which interplays with oxidative stress directly or indirectly. Antihyperglycemic agent metformin and newly found free radicals scavengers, Sirt1 and CTRP9, may serve as promising pharmacological therapeutic targets. In this review, we will focus on the role of oxidative stress and mTOR signaling in the pathophysiology of MI/R injury in diabetes and discuss potential mechanisms and their interactions in an effort to provide some evidence for cardiometabolic targeted therapies for ischemic heart disease (IHD).
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#2Cécile Dufeys (UCL: Université catholique de Louvain)H-Index: 4
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#1Tamás Baranyai (Semmelweis University)H-Index: 8
#2Csilla Terézia Nagy (Semmelweis University)H-Index: 3
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#1Toshinori Aoyagi (U.H.: University of Hawaii at Manoa)H-Index: 3
#2Jason K. Higa (U.H.: University of Hawaii at Manoa)H-Index: 6
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#1Mingming Zhang (Fourth Military Medical University)H-Index: 13
#2Dongdong Sun (Fourth Military Medical University)H-Index: 18
Last.Haichang Wang (Fourth Military Medical University)H-Index: 33
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#1Nan-Bo Liu (Academy of Medical Sciences, United Kingdom)
#2Min Wu (Academy of Medical Sciences, United Kingdom)
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View next paperOxidative stress and myocardial injury in the diabetic heart.