Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
Abstract
Base editing induces single-nucleotide changes in the DNA of living cells using a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision repair. This genome editing approach has the advantage that it does not require formation of double-stranded DNA breaks or provision of a donor DNA template. Here we report the development of five C to T (or G to A) base editors...
Paper Details
Title
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
Published Date
Feb 13, 2017
Journal
Volume
35
Issue
4
Pages
371 - 376
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