Base excision repair of oxidative DNA damage from mechanism to disease
Abstract
Reactive oxygen species continuously assault the structure of DNA resulting in oxidation and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair mediate the progression of many prevalent human maladies. The major pathway tasked with removal of oxidative DNA damage, and hence maintaining genomic integrity, is base excision repair (BER). The aphorism that structure often dictates function has proven true, as numerous...
Paper Details
Title
Base excision repair of oxidative DNA damage from mechanism to disease
Published Date
Jan 1, 2017
Journal
Volume
22
Issue
9
Pages
1493 - 1522
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