High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

Volume: 9, Issue: 377
Published: Feb 15, 2017
Abstract
Tyrosine kinase inhibitors (TKIs), despite their efficacy as anticancer therapeutics, are associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healthy individuals and 2 patients receiving cancer treatment, to screen U.S. Food and Drug Administration-approved TKIs for cardiotoxicities by measuring alterations...
Paper Details
Title
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
Published Date
Feb 15, 2017
Volume
9
Issue
377
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