Endogenous DNA Damage as a Source of Genomic Instability in Cancer
Abstract
Genome instability, defined as higher than normal rates of mutation, is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. On the other hand, genomic instability can have catastrophic consequences for age-related diseases such as cancer. Mutations arise either from inactivation of DNA repair pathways or in a repair-competent background due to genotoxic stress from celluar...
Paper Details
Title
Endogenous DNA Damage as a Source of Genomic Instability in Cancer
Published Date
Feb 1, 2017
Journal
Volume
168
Issue
4
Pages
644 - 656
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