Original paper
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
Abstract
Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events...
Paper Details
Title
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
Published Date
Feb 10, 2017
Journal
Volume
9
Issue
1
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Notes
History