Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias

Objective:

To assess the utility of serum neurofilament for diagnosis and monitoring of primary progressive aphasia (PPA) variants.

Methods:

We investigated neurofilament light chain (NF-L) levels in blood of 99 patients with PPA (40 with nonfluent variant PPA [nfvPPA], 38 with semantic variant PPA [svPPA], 21 with logopenic variant PPA [lvPPA]) and compared diagnostic performance with that reached by CSF NF-L, phosphorylated...