Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases
Abstract
“Cellular senescence” is a state in which cells undergo irreversible cell cycle arrest in response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to any mitogens, including oncogenic stimuli. Therefore, cellular senescence has been assumed to be a potent anticancer mechanism. Although irreversible cell‐cycle arrest is traditionally considered the major characteristic of senescent cells, recent studies have...
Paper Details
Title
Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases
Published Date
Apr 1, 2017
Journal
Volume
108
Issue
4
Pages
563 - 569
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Notes
History