FoxM1-mediated RFC5 expression promotes temozolomide resistance
Abstract
Although methylguanine-DNA-methyltransferase (MGMT) plays an important role in resistance to temozolomide (TMZ) in glioma, 40% of gliomas with MGMT inactivation are still resistant to TMZ. The underlying mechanism is not clear. Here, we report that forkhead box M1 (FoxM1) transcriptionally activates the expression of DNA repair gene replication factor C5 (RFC5) to promote TMZ resistance in glioma cells independent of MGMT activation. We showed...
Paper Details
Title
FoxM1-mediated RFC5 expression promotes temozolomide resistance
Published Date
Feb 9, 2017
Journal
Volume
33
Issue
6
Pages
527 - 537
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