P039 Suppression of phospholipase A2 of intestinal microbiota by the phospholipid-bile acid conjugate ursodeoxycholate-lysophoshatidylethanolamide ameliorates mucosal inflammation in a genetic mouse model of ulcerative colitis

Background: The mucosal attack by commensal microbiota is one component for induction of inflammatory episodes in ulcerative colitis (UC). Previously we could show that in UC the mucus layer is intrinsically devoid of phosphatidylcholine (PC) resulting in low hydrophobicity which facilitates bacterial invasion. Ectophospholipase carrying bacterial strains are most likely candidates to break the PC mucus barrier. Our aim of this study was to...