Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair

Volume: 45, Issue: 8, Pages: 4507 - 4518
Published: Feb 7, 2017
Abstract
The tumor suppressor BRCA2 is a large multifunctional protein mutated in 50–60% of familial breast cancers. BRCA2 interacts with many partners and includes multiple regions with potentially disordered structure. In homology directed DNA repair BRCA2 delivers RAD51 to DNA resulting in removal of RPA and assembly of a RAD51 nucleoprotein filament. Dynamic rearrangements of BRCA2 likely drive this molecular hand-off initiating DNA strand exchange....
Paper Details
Title
Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair
Published Date
Feb 7, 2017
Volume
45
Issue
8
Pages
4507 - 4518
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