SiRen: Leveraging Similar Regions for Efficient and Accurate Variant Calling

: Next-generation genomic sequencing costs are rapidly decreasing, having recently reached the $1000-per-genome barrier, a likely tipping point for widespread clinical use. However, genomic analysis techniques have failed to keep pace. In particular, the process of variant calling, or inferring a sample genome from the noisy sequencing data, introduces major computational and statistical challenges. In this work, we explore the feasibility of a...