Epigallocatechin gallate induces an up‐regulation of LDL receptor accompanied by a reduction of PCSK9 via the annexin A2‐independent pathway in HepG2 cells

Scope In animal studies, epigallocatechin gallate (EGCG), the dominant catechin in green tea, has been shown to improve cholesterol metabolism. However, the molecular mechanisms of EGCG underlying these functions have not been fully understood. In this study, we aimed to clarify the molecular mechanisms of the effect of EGCG on cholesterol metabolism mainly in HepG2 cells. Methods and results We found that EGCG induced a reduction of the...