CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6
Abstract
The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide...
Paper Details
Title
CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6
Published Date
Feb 7, 2017
Journal
Volume
45
Issue
6
Pages
3280 - 3296
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