High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations

Volume: 6, Issue: 3, Pages: e1284719 - e1284719
Published: Jan 31, 2017
Abstract
Immunotherapy with checkpoint inhibitors, such as antibodies blocking the programmed cell-death receptor-1 (PD-1), has resulted in remarkable responses in patients having traditionally refractory cancers. Although response to PD-1 inhibitors correlates with PD-1 ligand (PD-L1 or PD-L2) expression, PD-1 ligand positivity represents only a part of the predictive model necessary for selecting patients predisposed to respond to immunotherapy. We...
Paper Details
Title
High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations
Published Date
Jan 31, 2017
Volume
6
Issue
3
Pages
e1284719 - e1284719
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