An Optimized Procedure for the Site-Directed Labeling of NGF and proNGF for Imaging Purposes

Neurotrophins are growth factors of fundamental importance for the development, survival and maintenance of different neuronal and non-neuronal populations. Over the years, the use of labelled neurotrophins has helped in the study of their biological functions, leading to a better understanding of the processes that regulate their transport, traffic and signalling. However, the diverse and heterogeneous neurotrophin labelling strategies adopted...