Photopharmacological Modulation of Lipid-Gated TRPC Channels as a Strategy to Govern Neuronal Excitability
Abstract
Lipid-gated, TRPC channel isoforms 3, 6 and 7 are widely expressed in the brain. Although, cellular regulation and signalling functions of these proteins are well characterized in overexpressing systems, their role in native cells is incompletely understood. Recent evidence suggests a complex, inverse coupling between TRPC3 constitutive activity and hippocampal excitability, potentially involving promotion of a Ca2+-activated K+ conductance and...
Paper Details
Title
Photopharmacological Modulation of Lipid-Gated TRPC Channels as a Strategy to Govern Neuronal Excitability
Published Date
Feb 3, 2017
Journal
Volume
112
Issue
3
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