SERINC5 Inhibits HIV Fusion through Inactivation of Env Glycoproteins and Interference with Productive Refolding of Env

The multispan membrane proteins, SERINC3 and SERINC5, have been recently shown to incorporate into HIV-1 particles and compromise their ability to fuse with target cells – an effect that is antagonized by the viral accessary protein Nef. Env glycoproteins from different HIV-1 strains exhibit variable levels of sensitivity to SERINC-mediated restriction. The mechanism by which SERINCs interfere with HIV-1 fusion remains unclear. Here, we show by...