Interdomain Conformational Changes in Visual Arrestin upon Binding to Different Forms of Rhodopsin

Visual arrestin (arrestin-1) and its C-terminally truncated splice variant p44 reside in photoreceptor cells, regulating the desensitization of rhodopsin by blocking G protein signalling. The binding of full-length arrestin-1 is highly specific to phosphorylated light-activated rhodopsin (P-Rh∗); however, p44 is capable of binding to different forms of rhodopsin, including unphosphorylated light-activated rhodopsin, dark phosphorylated...