Zinc rescues obesity‐induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress‐activated BCL10/CARD9/p38 MAPK pathway

Obesity often leads to obesity‐related cardiac hypertrophy ( ORCH ), which is suppressed by zinc‐induced inactivation of p38 mitogen‐activated protein kinase (p38 MAPK ). In this study, we investigated the mechanisms by which zinc inactivates p38 MAPK to prevent ORCH . Mice (4‐week old) were fed either high fat diet ( HFD , 60% kcal fat) or normal diet ( ND , 10% kcal fat) containing variable amounts of zinc (deficiency, normal and supplement)...