Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank
Abstract
Gil McVean and colleagues present a new Bayesian analysis framework that exploits the hierarchical structure of diagnosis classifications to analyze genetic variants against UK Biobank disease phenotypes derived from self-reporting and hospital episode statistics. Their method displays increased power to detect genetic effects over other approaches and identifies novel associations between classical HLA alleles and common immune-mediated...
Paper Details
Title
Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank
Published Date
Jul 31, 2017
Journal
Volume
49
Issue
9
Pages
1311 - 1318
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