Late‐onset circulatory collapse of prematurity

Late‐onset circulatory collapse ( LCC ) is a refractory hypotension occurring after the early neonatal period (>day 7), in very low‐birthweight infants. Typically, infants stabilized within the early neonatal period develop sudden onset of circulatory collapse after the early neonatal period. The underlying pathophysiology of LCC is considered to be relative adrenal insufficiency, which is well known in Japan, but is not widely accepted in...