Interspecies Chimerism with Mammalian Pluripotent Stem Cells

Cell64.50
Volume: 168, Issue: 3, Pages: 473 - 486
Published: Jan 26, 2017
Abstract
Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several tissues of gene-edited organogenesis-disabled mice. Besides gaining insights into species evolution, embryogenesis, and human disease, interspecies...
Paper Details
Title
Interspecies Chimerism with Mammalian Pluripotent Stem Cells
Published Date
Jan 26, 2017
Journal
Volume
168
Issue
3
Pages
473 - 486
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