Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice

103 Background: Besides its well-known role in initiation and propagation of thrombus formation, thrombin may have multiple pro-atherogenic actions. Hypothesis: Pharmacologic thrombin inhibition attenuates the onset and progression of atherosclerosis and favors plaque stability in hypercoagulable mice prone to aggressive atherosclerosis development. Methods and Results: Hypercoagulability in TMPro/Pro:ApoE−/− mice resulted in severe...