Puerarin Suppresses Macrophage Activation via Antioxidant Mechanisms in a CaPO<sub>4</sub>-Induced Mouse Model of Aneurysm

Aneurysm is characterized by balloon-like expansion of the arterial wall and eventual rupture of the aorta. The pathogenesis of aneurysm is associated with the degradation of matrix proteins by matrix metalloproteinases (MMPs) produced by activated macrophages. Although aneurysm is associated with significant mortality and morbidity, surgical intervention is the only proven treatment strategy. Therefore, development of therapeutic agents for...