Saturated Fat Consumption and Risk of Coronary Heart Disease and Ischemic Stroke : A Science Update

Published on Jan 1, 2017in Annals of Nutrition and Metabolism3.051
· DOI :10.1159/000455681
Joyce A. Nettleton7
Estimated H-index: 7
Ingeborg A. Brouwer40
Estimated H-index: 40
+ 1 AuthorsGerard Hornstra44
Estimated H-index: 44
At a workshop to update the science linking saturated fatty acid (SAFA) consumption with the risk of coronary heart disease (CHD) and ischemic stroke, invited participants presented data on the consum
  • References (95)
  • Citations (21)
📖 Papers frequently viewed together
766 Citations
384 Citations
12 Authors (Frank M. Sacks, ..., Linda Van Horn)
219 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Geng Zong (Harvard University)H-Index: 21
#2Yanping Li (Harvard University)H-Index: 54
Last. Qi Sun (Harvard University)H-Index: 68
view all 8 authors...
Objectives To investigate the association between long term intake of individual saturated fatty acids (SFAs) and the risk of coronary heart disease, in two large cohort studies. Design Prospective, longitudinal cohort study. Setting Health professionals in the United States. Participants 73 147 women in the Nurses’ Health Study (1984-2012) and 42 635 men in the Health Professionals Follow-up Study (1986-2010), who were free of major chronic diseases at baseline. Main outcome measure Incidence o...
63 CitationsSource
#1Mu Chen (Harvard University)H-Index: 11
#2Yanping LiH-Index: 54
Last. Frank B. Hu (Harvard University)H-Index: 214
view all 9 authors...
BACKGROUND: Few prospective studies have examined dairy fat in relation to cardiovascular disease (CVD). OBJECTIVE: We aimed to evaluate the association between dairy fat and incident CVD in US adults. DESIGN: We followed 43,652 men in the Health Professionals Follow-Up Study (1986-2010), 87,907 women in the Nurses' Health Study (1980-2012), and 90,675 women in the Nurses' Health Study II (1991-2011). Dairy fat and other fat intakes were assessed every 4 y with the use of validated food-frequenc...
51 CitationsSource
#1Winfried MärzH-Index: 94
#2Hubert Scharnagl (Medical University of Graz)H-Index: 31
Last. Ulrich LaufsH-Index: 71
view all 10 authors...
Decreasing low-density lipoprotein cholesterol (LDL-C) is one of the few established and proven principles for the prevention and treatment of atherosclerosis. The higher the individual cardiovascular risk, the higher the benefit of lipid-lowering pharmacotherapy. Therefore, treatment options are chosen based on a patient’s total cardiovascular risk. The latter depends not only on the levels of LDL-C but also on the presence of cardiovascular disease (CVD) and on the number and severity of other...
12 CitationsSource
Objective— We assessed whether the association between dietary saturated fatty acids (SFA) and incident coronary heart disease (CHD) depends on the food source, the carbon chain length of SFA, and the substituting macronutrient. Approach and Results— From the Rotterdam Study, 4722 men and women (≥55 years) were included. Baseline (1990–1993) SFA intake was assessed using a validated food frequency questionnaire. CHD (nonfatal myocardial infarction and fatal CHD) was ascertained by medical record...
16 CitationsSource
#1Yan Li (Capital Medical University)H-Index: 19
#2Chao Li (Capital Medical University)H-Index: 1
Last. Jie Gao (Capital Medical University)H-Index: 1
view all 3 authors...
Abstract Background It has been reported that three common loci, SstI, C-482T, and T-455C, in the apolipoprotein C3 (APOC3) gene might be associated with an increased risk of coronary heart disease (CHD). Considering the inconsistent results and ethnicity variations, we performed a systematic meta-analysis to evaluate the association between three single nucleotide polymorphisms (SNPs) and the risk of CHD. Methods We searched HuGE Navigator and PubMed databases to screen for the related literatu...
5 CitationsSource
#1Daan KromhoutH-Index: 109
#2C J K SpaaijH-Index: 1
Last. R M WeggemansH-Index: 1
view all 4 authors...
The objective of this study was to derive food-based dietary guidelines for the Dutch population. The dietary guidelines are based on 29 systematic reviews of English language meta-analyses in PubMed summarizing randomized controlled trials and prospective cohort studies on nutrients, foods and food patterns and the risk of 10 major chronic diseases: coronary heart disease, stroke, heart failure, diabetes, breast cancer, colorectal cancer, lung cancer, chronic obstructive pulmonary disease, deme...
78 CitationsSource
#1Wijtske Annema (UZH: University of Zurich)H-Index: 18
#2A. von Eckardstein (UZH: University of Zurich)H-Index: 76
Low plasma levels of high-density lipoprotein (HDL) cholesterol are associated with increased risks of coronary heart disease. HDL mediates cholesterol efflux from macrophages for reverse transport to the liver and elicits many anti-inflammatory and anti-oxidative activities which are potentially anti-atherogenic. Nevertheless, HDL has not been successfully targeted by drugs for prevention or treatment of cardiovascular diseases. One potential reason is the targeting of HDL cholesterol which doe...
29 CitationsSource
#1Laurence Eyres (University of Otago)H-Index: 1
#2Michael F. Eyres (University of Otago)H-Index: 1
Last. Rachel C. Brown (University of Otago)H-Index: 19
view all 4 authors...
Coconut oil is being heavily promoted as a healthy oil, with benefits that include support of heart health. To assess the merits of this claim, the literature on the effect of coconut consumption on cardiovascular risk factors and outcomes in humans was reviewed. Twenty-one research papers were identified for inclusion in the review: 8 clinical trials and 13 observational studies. The majority examined the effect of coconut oil or coconut products on serum lipid profiles. Coconut oil generally r...
53 CitationsSource
#1Pengfei Cheng (Jiamusi University)H-Index: 2
#2Jingxia Wang (Jiamusi University)H-Index: 2
Last. Hui Zhang (Jiamusi University)H-Index: 1
view all 5 authors...
We conducted a meta-analysis to summarize available evidence regarding the relation between saturated fatty acid (SFA) intake and stroke risk. We searched multiple electronic databases through February 2016. Log relative risks (RRs) with 95 % confidence intervals (CIs) of the highest versus the lowest for cohort studies were weighed by the inverse variance method to obtain combined RRs. 15 prospective studies including 476,569 individuals and 11,074 strokes were included. Higher SFA intake was a...
8 CitationsSource
#1Paolo Zanoni (UPenn: University of Pennsylvania)H-Index: 6
#2Sumeet A. Khetarpal (UPenn: University of Pennsylvania)H-Index: 14
Last. Daniel J. Rader (UPenn: University of Pennsylvania)H-Index: 140
view all 49 authors...
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying gene...
191 CitationsSource
Cited By21
#1Cecilia Guastadisegni (ISS: Istituto Superiore di Sanità)H-Index: 9
#2Chiara Donfrancesco (ISS: Istituto Superiore di Sanità)H-Index: 21
Last. Simona Giampaoli (ISS: Istituto Superiore di Sanità)H-Index: 53
view all 10 authors...
The aim of this study is to evaluate whether nutrients intake in an Italian adult population receiving pharmacological treatment for hypertension, dyslipidemia, and diabetes are within the recommended values proposed by dietary guidelines. Cross-sectional data from the Cardiovascular Epidemiology Observatory/Health Examination Survey in 8462 individuals 35–79 years were used. Food consumption was assessed with a self-administered semi-quantitative food frequency questionnaire. Dietary sodium and...
Abstract Background and Aims Due to the conflicting research results, the association of saturated fatty acid (SFA) consumption and the risk of stroke remains controversial. We conducted a meta-analysis to evaluate potential dose-response relations between SFA intake and stroke. Methods and Results PubMed, Embase, the Cochrane Library Central Register of Controlled Trials and Web of Science were searched. Summary relative risks (RRs) of the highest vs. the lowest category of SFA intake and their...
1 CitationsSource
#1Alejandro G. Marangoni (U of G: University of Guelph)H-Index: 58
#2John P. M. van Duynhoven (WUR: Wageningen University and Research Centre)H-Index: 33
Last. Ashok R. Patel (Technion – Israel Institute of Technology)H-Index: 31
view all 5 authors...
The reasons for the increased world-wide incidence of obesity, type-2 diabetes, and cardiovascular disease include sedentary lifestyles and poor food choices. Regulatory agencies in several countries now require companies to add unattractive front of package labels to their products where salt, sugar and fat (or saturated fat) levels are prominently displayed. After the demise of partially hydrogenated fats, saturated fat has become the new target. Consumption of saturated fat over polyunsaturat...
#2Anna TagliabueH-Index: 1
Last. Cinzia FerrarisH-Index: 7
view all 3 authors...
#1Ashok R. Patel (Technion – Israel Institute of Technology)H-Index: 31
A range of dairy products are consumed on a regular basis as sources of macronutrients (fats and proteins) and micronutrients such as minerals and fat-soluble vitamins. Among these, there are products such as butter and cheese that form a part of daily diets and then there are others such as whipped cream and ice-creams that are usually considered as indulgence products. From colloid science point of view, these products could be broadly classified as structured emulsions (butter and butter spre...
#1Surangi H Thilakarathna (U of G: University of Guelph)H-Index: 2
#2Samar Hamad (U of G: University of Guelph)H-Index: 1
Last. Amanda J. Wright (U of G: University of Guelph)H-Index: 25
view all 5 authors...
BACKGROUND: The presence of triacylglycerol (TAG) cystallinity is assumed to influence digestibility and postprandial lipemia (PPL), although studies to date are limited. OBJECTIVE: This study aimed to investigate whether the presence of solid fat compared with undercooled liquid oil, specifically, plays a role in determining PPL by comparing emulsion droplets differing only in terms of physical state. METHODS: Ten percent palm stearin and 0.4% sorbitan monostearate emulsions were tempered to co...
1 CitationsSource
#1Siniša Đurašević (University of Belgrade)H-Index: 1
#2Gorana V. Nikolić (University of Belgrade)H-Index: 1
Last. Zoran Todorovic (University of Belgrade)H-Index: 11
view all 9 authors...
Abstract Non-diabetic and alloxan-induced diabetic rats were fed with standard laboratory food enriched with 20% virgin coconut oil for 16 weeks. In non-diabetic animals coconut oil improved insulin sensitivity and ability to control glycaemia and decreased the serum triglycerides for almost 50% in comparison with controls. Supplementation with coconut oil caused liver steatosis in both non-diabetic and diabetic animals. However, the severity of steatosis was lower in diabetic animals compared t...
1 CitationsSource
#1Areen Ashkar (Technion – Israel Institute of Technology)H-Index: 2
#2Sharon Laufer (Technion – Israel Institute of Technology)H-Index: 1
Last. Maya Davidovich-Pinhas (Technion – Israel Institute of Technology)H-Index: 16
view all 5 authors...
Abstract Oil structuring has been proposed as a promising strategy for fat replacement due to its solid texture and high unsaturation content. Oil structuring can be achieved using various gelator types, which induce oil gelation via various mechanisms. This research investigated the relation between the different gelators and gelation mechanisms, i.e. crystalline or polymer network, to the mechanical and rheological properties as well as their responsiveness to digestive lipolysis under simulat...
4 CitationsSource
#1Anna Maria Cybulska (Pomeranian Medical University)
#2Karolina Skonieczna-Żydecka (Pomeranian Medical University)H-Index: 9
Last. Elżbieta Grochans (Pomeranian Medical University)H-Index: 9
view all 8 authors...
Menopause, the permanent cessation of the menstrual cycle, marks the end of a woman’s reproductive lifespan. Menopausal hormonal therapy (MHT) can potentially skew the fatty acid profile increasing the risk for developing metabolic diseases and disorders of skeletal, gastrointestinal, and nervous systems. The aim of this study was to investigate the fatty acid profile of postmenopausal women receiving, and not receiving, hormone replacement therapy. A total of 156 healthy women with a mean age o...