The human longevity gene homolog INDY and interleukin‐6 interact in hepatic lipid metabolism

Reduced expression of the Indy (“I am Not Dead, Yet”) gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy ( mIndy, Slc13a5 ) encoding for a plasma membrane–associated citrate transporter expressed highly in the liver, protects mice from high‐fat diet–induced and aging‐induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We...