Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells
Abstract
A large number of drugs can induce prolongation of cardiac repolarization and life-threatening cardiac arrhythmias. The prediction of this side effect is however challenging as it usually develops in some genetically predisposed individuals with normal cardiac repolarization at baseline. Here, we describe a platform based on a genetically diverse panel of induced pluripotent stem cells (iPSCs) that reproduces susceptibility to develop a...
Paper Details
Title
Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells
Published Date
Jan 30, 2017
Journal
Volume
6
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