Absolute Configuration Determination of a Taxol Precursor Based on Raman Optical Activity Spectra
Abstract
Enantiomeric purity of drugs is essential for their biological activity. In the present study, we investigate the performance of Raman optical activity (ROA) spectroscopy in distinguishing four possible stereoisomers of the synthetic precursor used for the production of taxol from baccatin III. Taxol is one of the best-selling medicaments used in the treatment of ovarian, lung, and breast cancers and Kaposi’s sarcoma. In a low yield, it may be...
Paper Details
Title
Absolute Configuration Determination of a Taxol Precursor Based on Raman Optical Activity Spectra
Published Date
Feb 13, 2017
Volume
121
Issue
7
Pages
1544 - 1551
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