Bacteriophages targeting adherent invasive Escherichia coli strains as a promising new treatment for Crohn's disease

Adherent invasive Escherichia coli [AIEC] are abnormally predominant on the ileal mucosa of Crohn's disease [CD] patients. They bind to the CEACAM6 receptor expressed on the surface of epithelial cells. We aimed to assess the potential of bacteriophages, viruses infecting bacteria, to decrease the levels of AIEC bacteria associated with the intestinal mucosa.We combined ex vivo and in vivo experiments with murine and human intestinal samples to...