Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process
Abstract
Non-homologous end-joining (NHEJ) is the dominant means of repairing chromosomal DNA double strand breaks (DSBs), and is essential in human cells. Fifteen or more proteins can be involved in the detection, signalling, synapsis, end-processing and ligation events required to repair a DSB, and must be assembled in the confined space around the DNA ends. We review here a number of interaction points between the core NHEJ components (Ku70, Ku80,...
Paper Details
Title
Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process
Published Date
Jan 30, 2017
Journal
Volume
39
Issue
3
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