Structural insights into the mechanism of the DEAH-box RNA helicase Prp43
Abstract
The DEAH-box helicase Prp43 is a key player in pre-mRNA splicing as well as the maturation of rRNAs. The exact modus operandi of Prp43 and of all other spliceosomal DEAH-box RNA helicases is still elusive. Here, we report crystal structures of Prp43 complexes in different functional states and the analysis of structure-based mutants providing insights into the unwinding and loading mechanism of RNAs. The Prp43•ATP-analog•RNA complex shows the...
Paper Details
Title
Structural insights into the mechanism of the DEAH-box RNA helicase Prp43
Published Date
Jan 16, 2017
Journal
Volume
6
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