Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

Published on Jan 12, 2017
· DOI :10.3390/inorganics5010004
Younes Ellahioui3
Estimated H-index: 3
Sanjiv Prashar12
Estimated H-index: 12
Santiago Gómez-Ruiz26
Estimated H-index: 26
For more than 100 years metal complexes have been extensively used in therapy and since the discovery of cisplatin the research in this field has expanded exponentially. The scientific community is always in search of new alternatives to platinum compounds and a wide variety of metallodrugs based on other metals have been reported with excellent therapeutic results. This short review focuses on the work that our research group has carried out since 2007 in collaboration with others and centers on the preparation of organogallium(III) compounds, organotin(IV) derivatives, and titanocene(IV) complexes together with the study of their cytotoxic anticancer properties.
  • References (72)
  • Citations (16)
📖 Papers frequently viewed together
31 Citations
359 Citations
87 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Denise Hübner (Leipzig University)H-Index: 1
Last. Goran N. Kaluđerović (Leibniz Association)H-Index: 27
view all 4 authors...
Two ionic triphenyltin(IV) chloride carboxylato compounds of the formula [NHEt3][Ph3SnCl(L)] (LH = N-phthaloylglycine (P-GlyH), 1; 1,2,4-benzenetricarboxylic 1,2-anhydride (BTCH), 2) were tested for the in vitro activity against 518A2 (melanoma), FaDu (head and neck carcinoma), HT-29 (colon cancer), MCF-7 (breast carcinoma) and SW1736 (thyroid cancer) cell lines. The ammonium salts of carboxylic acids are found to be not active, while anionic [Ph3SnCl(L)]– exhibited high cytotoxicity in nM range...
1 CitationsSource
#1Li Ming GaoH-Index: 7
#2Wilson MaldonadoH-Index: 1
Last. Enrique MeléndezH-Index: 16
view all 6 authors...
Estrogen receptor alpha (ERα) is a transcription factor that is activated by hormones, with 17β-estradiol being its most active agonist endogenous ligand. ERα is also activated or inactivated by exogenous ligands. ER is overexpressed in hormone-dependent breast cancer, and one of the treatments for this type of cancer is the use of an ER antagonist to halt cell proliferation. We have previously reported four steroid-functionalized titanocenes: pregnenolone, dehydroepiandrosterone (DHEA), trans-a...
4 CitationsSource
#1Christian Bensing (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 3
#2Marija Mojić (University of Belgrade)H-Index: 13
Last. Goran N. Kaluđerović (Leibniz Association)H-Index: 27
view all 8 authors...
SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 a...
11 CitationsSource
#1Belén Fernández (UGR: University of Granada)H-Index: 17
#2Itziar Oyarzabal (UPV/EHU: University of the Basque Country)H-Index: 14
Last. Antonio Rodríguez-Diéguez (UGR: University of Granada)H-Index: 25
view all 8 authors...
A novel metal–organic chain constructed of dysprosium and sodium ions based on 5-aminopyridine-2-carboxylic acid has been synthesized and characterized. The formation of this 1D-MOF is achieved using a soft solvothermal route with dimethylformamide as solvent. This material displays intense photoluminescence properties in the solid state at room temperature and exhibits SIM behavior with frequency dependence of the out-of-phase susceptibility at zero dc field. More interesting, we report here th...
12 CitationsSource
#1Waseem A. Wani (UTM: Universiti Teknologi Malaysia)H-Index: 18
#2Sanjiv Prashar (URJC: King Juan Carlos University)H-Index: 21
Last. Santiago Gómez-Ruiz (URJC: King Juan Carlos University)H-Index: 26
view all 4 authors...
Abstract Nanotechnology has shown great promise in unraveling several important issues of conventional anticancer chemotherapy. Expectations project that a new generation of effective cancer therapies will be developed with enormous potential to overcome the biological, biophysical and biomedical obstacles that the human body enacts against standard chemotherapeutic treatments. Generally, nanostructures protect the entombed drug molecules from degradation in blood, allowing their safe and unimpa...
87 CitationsSource
In vitro antitumor activity of various organogallium(III) complexes (1–8) has been tested against CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used to assess on the antiproliferative effect of investigated organogallium(III) complexes. From the investigated complexes, the most active was found to be tetranuclear compound 8 against CT26CL25 cells. Flow cytometric analysis of the CT26CL25 cells upon the treatment with 8 was performed in order to determine the role of apo...
5 CitationsSource
#1Jennie L. WilliamsH-Index: 16
Last. Alvin A. HolderH-Index: 16
view all 14 authors...
3 CitationsSource
#2Sanjiv PrasharH-Index: 12
Last. Santiago Gómez-RuizH-Index: 26
view all 7 authors...
The synthesis of the ether-substituted group 4 metallocene complexes [Ti(η5-C5H5)(η5-C5H4{CMeRCH(OMe)2})Cl2] (R = Me (4), Ph (5)) and [M(η5-C5H4{CMeRCH(OMe)2})2Cl2] (M = Ti, R = Me (6), Ph (7); M = Zr, R = Me (8), Ph (9)) is reported. In addition, the titanocene derivatives 4–7 have been supported on the mesoporous silica-based material KIT-6, giving the functionalized materials K4–K7, respectively. All compounds and materials have been characterized by different analytical techniques such as so...
11 CitationsSource
#1Sónia Barroso (IST: Instituto Superior Técnico)H-Index: 11
#2Ana M. Coelho (IST: Instituto Superior Técnico)H-Index: 3
Last. Ana M. Martins (IST: Instituto Superior Técnico)H-Index: 32
view all 7 authors...
Correction for ‘Synthesis, cytotoxic and hydrolytic studies of titanium complexes anchored by a tripodal diamine bis(phenolate) ligand’ by Sonia Barroso et al., Dalton Trans., 2014, 43, 17422–17433.
2 CitationsSource
#1Santiago Gómez-Ruiz (URJC: King Juan Carlos University)H-Index: 26
#2Željko ŽižakH-Index: 16
Last. Goran N. Kaluđerović (Leibniz Association)H-Index: 27
view all 3 authors...
Abstract The reaction of α,α′-dimercapto- o -xylene (H 2 dmox) with SnPh 2 Cl 2 (1:1) and SnPh 3 Cl (1:2) in the presence of two equivalents of NEt 3 led to the formation of the complexes [SnPh 2 (dmox)] ( 1 ) and [SnPh 3 ( μ -dmox)] 2 ( 2 ), respectively. Both complexes have been characterized by multinuclear NMR and IR spectroscopy, mass spectrometry and elemental analysis. In addition, the molecular structure of complex 2 has been determined by single crystal X-ray diffraction studies. The cy...
4 CitationsSource
Cited By16
#1Tatenda Madanhire (Sciences Po)
#2Hajierah Davids (Sciences Po)
Last. Abubak'r Abrahams (Sciences Po)
view all 5 authors...
Abstract The complexation reactions of Ce(III), Nd(III), Gd(III) and Er(III) ions with the chelating/ bridging monoanionic ligand N-(2,6-dimethylphenyl)oxamate (Hpma–) in basic media were performed in view of the potential applications of oxamate derivatives as cytotoxic agents. The coordination compounds were characterised by different physico-chemical techniques: elemental analysis, conductivity measurements, IR, 1H NMR and UV-Vis-NIR spectroscopy, and X-ray crystallography. The anionic Hpma– ...
#1Fatemeh Delavar Mendi (FUM: Ferdowsi University of Mashhad)H-Index: 1
#2Amir Sh. Saljooghi (FUM: Ferdowsi University of Mashhad)H-Index: 1
Last. Mona Alibolandi (MUMS: Mashhad University of Medical Sciences)H-Index: 24
view all 10 authors...
In this study, five new complexes containing deferiprone (dfp) and N,N-donor ligands [bipyridine (bpy), 1,10-phenanthroline (phen) and ethylenediamine (en)] were synthesized: [Fe(dfp)2(bpy)](PF6) (1), [Fe(dfp)2(phen)](PF6) (2), [Cu2(dfp)2(bpy)2](PF6)2 (3), [Ga(dfp)2(bpy)](PF6) (4), and [Fe(dfp)2(en)](PF6) (5). Characterization of these complexes was carried out through elemental analysis and FT-IR, and single-crystal X-ray crystallography was used to determine their structures. Whilst the polyhe...
#1Diana Díaz-García (URJC: King Juan Carlos University)H-Index: 4
#2Karla Montalbán-Hernández (URJC: King Juan Carlos University)H-Index: 2
Last. Eva Fischer-FodorH-Index: 13
view all 11 authors...
The synthesis, characterization and cytotoxic activity against different cancer cell lines of various mesoporous silica-based materials containing folate targeting moieties and a cytotoxic fragment based on a triphenyltin(IV) derivative have been studied. Two different mesoporous nanostructured silica systems have been used: firstly, micronic silica particles of the MSU-2 type and, secondly, mesoporous silica nanoparticles (MSNs) of about 80 nm. Both series of materials have been characterized b...
#1Entsar A. Saad (Damietta University)H-Index: 7
#2Hala A. Kiwan (Damietta University)
Last. Hager E. Al-Adl (Damietta University)
view all 4 authors...
Abstract Rifampicin is a semi-synthetic derivative of rifamycin. It has a broad antibacterial activity. Iron is the most plentiful transition metal in human body. It is a crucial nutrient needed for numerous essential cellular functions. The present study is a trial to develop a novel antitumor candidate depending on formation of a complex between iron and rifampicin. After successful preparation, the resultant complex was characterized. Then its antitumor activity was investigated in vitro and ...
#1Farzana Shaheen (Allama Iqbal Open University)H-Index: 2
#2Muhammad Sirajuddin (University of Science and Technology)H-Index: 17
Last. Muhammad Nawaz Tahir (UOS: University of Sargodha)H-Index: 38
view all 6 authors...
A series of triorganotin(IV) compounds {Me3SnL (1), Bu3SnL (2), Ph3SnL (3)} and di-organotin(IV) complexes {Me2SnL2 (4), Bu2SnL2 (5) and Ph2SnL2 (6)}, where Me = methyl, Bu = butyl, Ph = phenyl and...
#1Sanchari Dasgupta (CU: University of Calcutta)H-Index: 7
#2Suhana Karim (CU: University of Calcutta)H-Index: 1
Last. Debasis Das (CU: University of Calcutta)H-Index: 21
view all 6 authors...
Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(II) complexes [Zn(L1)Cl2].2H2O(1), [Zn(L2)Cl2](2) and [Zn(L3)Cl2](3) were synthesized by treatment of zinc(II) chloride with corresponding Schiff base ligands and characterised by usual physicochemical techniques. The solid sta...
1 CitationsSource
Over time platinum-based anticancer drugs have dominated the market, but their side effects significantly impact the quality of life of patients. Alternative treatments are being developed all over the world. The titanocene and auranofin families of compounds, discovered through an empirical search for other metal-based therapeutics, hold tremendous promise to improve the outcomes of cancer treatment. Herein we present a historical perspective of these compounds and review current efforts focuse...
#1Karina Ovejero Paredes (Complutense University of Madrid)H-Index: 2
#2Diana Díaz-García (URJC: King Juan Carlos University)H-Index: 4
Last. Marco Filice (Complutense University of Madrid)H-Index: 19
view all 9 authors...
Three different multifunctional nanosystems based on the tethering onto mesoporous silica nanoparticles (MSN) of different fragments such as an organotin-based cytotoxic compound Ph3Sn{SCH2CH2CH2Si(OMe)3} (MSN-AP-Sn), a folate fragment (MSN-AP-FA-Sn), and an enzyme-responsive peptide able to release the metallodrug only inside cancer cells (MSN-AP-FA-PEP-S-Sn), have been synthesized and fully characterized by applying physico-chemical techniques. After that, an in vitro deep determination of the...
2 CitationsSource
#1Ayodele Temidayo Odularu (University of Fort Hare)H-Index: 2
#2Peter A. Ajibade (UKZN: University of KwaZulu-Natal)H-Index: 19
Last. Opeoluwa O. Oyedeji (University of Fort Hare)H-Index: 9
view all 4 authors...
Platinum-group (PG) complexes have been used as antibacterial and anticancer agents since the discovery of cisplatin. The science world still requires improvement on these complexes because of multidrug and antineoplastic resistances. This review observes discoverers and history of these platinum-group metals (PGMs), as well as their beneficial applications. The focus of this study was biological applications of PGMs in relation to human health. Sandwich and half-sandwich PGM coordination compou...
1 CitationsSource
#1Hussain Ullah (QAU: Quaid-i-Azam University)H-Index: 1
#2Viola Previtali (Trinity College, Dublin)H-Index: 1
Last. Isabel Rozas (Trinity College, Dublin)H-Index: 29
view all 9 authors...
Abstract There is a growing interest in the cancer cell growth inhibitory effects of organotin (IV) compounds and, accordingly, a new series of dimethyl-, di-( n -butyl)-, diphenyl- and chloro-phenyl tin(IV) complexes with a Schiff base core were prepared. Their binding to DNA was assessed by UV thermal denaturation showing no interaction and by UV–vis titration exhibiting moderate interaction by intercalation. Complexes having n -butyl substituents were more potent and cytotoxic against human l...
1 CitationsSource