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Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

Published on Jan 12, 2017
· DOI :10.3390/inorganics5010004
Younes Ellahioui3
Estimated H-index: 3
,
Sanjiv Prashar12
Estimated H-index: 12
,
Santiago Gómez-Ruiz26
Estimated H-index: 26
Abstract
For more than 100 years metal complexes have been extensively used in therapy and since the discovery of cisplatin the research in this field has expanded exponentially. The scientific community is always in search of new alternatives to platinum compounds and a wide variety of metallodrugs based on other metals have been reported with excellent therapeutic results. This short review focuses on the work that our research group has carried out since 2007 in collaboration with others and centers on the preparation of organogallium(III) compounds, organotin(IV) derivatives, and titanocene(IV) complexes together with the study of their cytotoxic anticancer properties.
  • References (72)
  • Citations (16)
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Two ionic triphenyltin(IV) chloride carboxylato compounds of the formula [NHEt3][Ph3SnCl(L)] (LH = N-phthaloylglycine (P-GlyH), 1; 1,2,4-benzenetricarboxylic 1,2-anhydride (BTCH), 2) were tested for the in vitro activity against 518A2 (melanoma), FaDu (head and neck carcinoma), HT-29 (colon cancer), MCF-7 (breast carcinoma) and SW1736 (thyroid cancer) cell lines. The ammonium salts of carboxylic acids are found to be not active, while anionic [Ph3SnCl(L)]– exhibited high cytotoxicity in nM range...
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Correction for ‘Synthesis, cytotoxic and hydrolytic studies of titanium complexes anchored by a tripodal diamine bis(phenolate) ligand’ by Sonia Barroso et al., Dalton Trans., 2014, 43, 17422–17433.
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