Hippo vs. Crab: tissue‐specific functions of the mammalian Hippo pathway

The Hippo signaling pathway is a vital suppressor of tumorigenesis that is often inactivated in human cancers. In normal cells, the Hippo pathway is triggered by external forces such as cell crowding, or changes to the extracellular matrix or cell polarity. Once activated, Hippo signaling down‐regulates transcription supported by the paralogous cofactors YAP 1 and TAZ . The Hippo pathway's functions in normal and cancer biology have been...