Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
Abstract
Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and –non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPRmt), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle–specific deficiency of Crif1 (muscle-specific...
Paper Details
Title
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
Published Date
Dec 16, 2016
Journal
Volume
216
Issue
1
Pages
149 - 165
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